Special Chemistries Proton’s innovative GenX line of Clinical Chemistry Reagents

ACE (Angiotensin Converting Enzyme)
GenX – ACE (Angiotensin Converting Enzyme)
  • For Extra Pulmonary Tuberculosis)
  • Liquid Stable, Ready to use Mono Reagent (With or without calibrator)
  • Incorporates GenX Technology.
  • 5 Minutes Kinetic Reaction. (60 Sec + 240 Sec.).
  • Linearity: 100 IU/L
  • Measuring Wavelength 340 nm.
  • No interference from Bilirubin up to 25 mg/dL, Hemoglobin up to 725 mg/dL, Lipaemia up to 1000 mg/dL, and Ascorbic acid up to 5 mg/dL.
  • Serum and Heparinizes Plasma are the specimens
  • Available as multipurpose reagents and dedicated system packs
Adenosine Deaminase (ADA) – Kinetic & Enzymatic (For Extrapulmonary Tuberculosis)
GenX – Adenosine Deaminase (ADA) (Kinetic/Enzymatic)
  • For Extra Pulmonary Tuberculosis)
  • Liquid Stable, Ready to use Two Reagents (With or without calibrator)
  • Incorporates GenX Technology.
  • 10 Minutes two step procedure. (5 Minutes First Incubation+ 5 Minutes Second Incubation)
  • Kinetic reaction time 300 sec (60 Sec + 240 Sec.).
  • Highly accurate cut offs’ for tuberculosis
  • Linearity: 250 IU/L
  • Measuring Wavelength 546 nm.
  • No interference from Bilirubin up to 25 mg/dL, Hemoglobin up to 200 mg/dL, Triglycerides up to 1000 mg/dL, and Ascorbic acid up to 6 mg/dL.
  • Pleural Fluid. Ascitic Fluid, Pericardial Fluid, Cerebrospinal Fluid, Serum or Heparinized/EDTA Plasma are to be used as specimens based on the clinical condition
  • Available as multipurpose reagents and dedicated system packs
Adenosine Deaminase (ADA) – Kinetic & Enzymatic (For Liver Cirrhosis)
GenX – HEP- ADA (Kinetic/Enzymatic) (For various forms of Hepatitis and Hepatic Cirrhosis)
  • Liquid Stable, Ready to use Two Reagents (With or without calibrator)
  • Incorporates GenX Technology.
  • 10 Minutes two step procedure. (5 Minutes First Incubation+ 5 Minutes Second Incubation)
  • Kinetic reaction time 300 sec (60 Sec + 240 Sec.).
  • Highly accurate cut offs’ for Hepatitis and Hepatic Cirrhosis
  • Linearity: 250 IU/L
  • Measuring Wavelength 546 nm.
  • No interference from Bilirubin up to 25 mg/dL, Hemoglobin up to 200 mg/dL, Triglycerides up to 1000 mg/dL, and Ascorbic acid up to 6 mg/dL.
  • Serum or Heparinized/EDTA Plasma are to be used as specimens.
  • Available as multipurpose reagents and dedicated system packs
Alcohol (Ethanol).
GenX – Alcohol (Enzymatic/UV)
  • Liquid Stable, Ready to use Two Reagents.
  • Incorporates GenX Technology.
  • 4 Minutes Fixed Time procedure (60 Sec + 180 Sec)
  • Linearity: 400 mg/dl
  • Measuring Wavelength 340 nm.
  • Aqueous Calibrator provided
  • Available as multipurpose reagents and dedicated system packs
Aldolase.
GenX – Aldolase (Enzymatic/UV)
  • Liquid Stable, Ready to use Two Reagents (With Calibrator)
  • Incorporates GenX Technology.
  • 5 Minutes Fixed Time procedure (60 Sec + 240 Sec)
  • Linearity: 60 IU/L
  • Measuring Wavelength 340 nm.
  • No interference from Bilirubin up to 25 mg/dL, Hemoglobin up to 200 mg/dL, Triglycerides up to 1000 mg/dL, and Intra Lipid 250 mg/dl
  • Available as multipurpose reagents and dedicated system packs
Ammonia Ultra.
GenX Ammonia –Ultra (GLDH-UV Method)
  • Liquid Stable, Ready to use Two Reagents
  • (R1= Buffer, R2=Substrate) , (4 parts R1+1 part R2)
  • Incorporates GenX Technology .
  • NADH analogues are used for better stability
  • 4 Minutes decreasing Fixed Time (Two Point) reaction (60 Sec Delay+180 Sec Measuring)
  • Working Reagent Stability 7 days at 2-8° C.
  • Measuring Wavelength 340 nm
  • Aqueous calibrator provided (Calibrator Conc: 300 µg/dl.)
  • Linearity 1000 µg/dl.
  • EDTA Plasma is the only specimen
  • Available as multipurpose reagents and dedicated system packs
Amylase (Pancreatic).
GenX Pancreatic Amylase (IFCC)
  • Liquid Stable, Ready to use Two Reagents
  • (R1= Buffer, R2=Substrate), (4 parts R1+1 part R2)
  • Uses blocked pNPG7 (EPS) as substrate
  • Immunoinhibition of Salivary Amylase by a mixture of two monoclonal antibodies
  • Linearity 1000 IU/L.
  • 2 Minutes increasing kinetic reaction (60 Sec Delay+60 Sec Measuring)
  • Working Reagent Stability 30 days at 2-8° C.
  • Results by kinetic factor.
  • Measuring Wavelength 405 nm
  • Serum or Heparinized Plasma as Specimen
  • Available as multipurpose reagents and dedicated system packs
Total Bile Acids (TBA)
GenX – Total Bile Acids (5th Generation Enzymatic Recycling Method)
  • Liquid Stable, Ready to use Two Reagents
  • 5 Minutes Kinetic reaction time 300 sec (60 Sec + 240 Sec.).
  • Linearity: 188 mMol/L
  • Measuring Wavelength: 405 nm (340 nm option available)
  • Serum or Heparinized/EDTA Plasma are to be used as specimens.
Calcium –ML ( 5th Generation, Phosphonazo III )
GenX – Calcium-ML 5th Gen (Phosphonazo III Method)
  • Liquid Stable, Ready to use Mono Reagent
  • Available as mono test packs.
  • One step End Point assay.
  • Superior over O-CPC and Arsenazo III Methods.
  • 38% more sensitive than Arsenazo III Method
  • 300% more sensitive than O-CPC Method
  • Aqueous Calcium standard provided (Standard Conc: 10 mg/dl)
  • Linearity: 25 mg/dL
  • Disposable calcium free test tubes provided for testing.
  • Measuring Wavelength 630 nm (600 – 650 nm)
  • Serum is the only specimen
  • Available as multipurpose reagents and dedicated system packs
Carbondioxide (Bicarbonate)
GenX – Carbondioxide (Bicarbonate)
  • Liquid Stable, Ready to use Two Reagents
  • Incorporates GenX Technology.
  • 5 Minutes Fixed Time Reaction. (60 Sec + 240 Sec.).
  • Linearity: 50 mMol/L
  • Measuring Wavelength 340 nm.
  • Aqueous Calibrator provided.
  • No interference from Bilirubin up to 19 mg/dL, Hemoglobin up to 520 mg/dL, Lipaemia up to 1000 mg/dL, and Ascorbic acid up to 5 mg/dL.
  • Un hemolyzed serum the only specimen
  • Available as multipurpose reagents and dedicated system packs
Cholinesterase
GenX – Cholinesterase ( Butyrylthiocholine Method)
  • Liquid Stable, Ready to use Three Reagents (R1, R2, R3)
  • 2 Minutes increasing Kinetic reaction (60 Sec Delay+60 Sec Measuring)
  • Measuring Wavelength 405 nm
  • Result by kinetic factor.
  • Linearity 16000 IU/L
  • Serum is the only specimen
  • Available as multipurpose reagents and dedicated system packs
Copper-ML
GenX – Copper-ML
  • Liquid Stable, Ready to use Mono Reagent
  • Incorporates GenX Technology.
  • Results correlate with that of Atomic Absorption method
  • 5 Minutes Fixed Time Reaction. (60 Sec + 240 Sec.).
  • Linearity: 500 µg/dl.
  • Measuring Wavelength 578 nm.
  • Aqueous Calibrator provided.
  • Un hemolyzed serum is the only specimen
  • Available as multipurpose reagents and dedicated system packs
Creatinine- Enzymatic
GenX – Creatinine (Enzymatic)
  • Liquid Stable, Ready to use Two Reagents
  • (R1= Buffer, R2=Substrate) , (4 parts R1+1 part R2)
  • 5 minutes fixed time reaction (60 sec Delay +240 sec Interval).
  • Incorporates GenX Technology .
  • Aqueous Creatinine standard provided (Standard Conc: 2 mg/dl)
  • Lipid Clearing Factor (LCF)
  • Linearity: 50 mg/dl
  • Measuring Wavelength 546 nm
  • Serum / Heparinized or EDTA Plasma / Diluted Urine as Specimens
  • Available as multipurpose reagents and dedicated system packs
Cystatin-C
GenX – Cystatin-C
  • Liquid Stable, Ready to use Two Reagents with Calibrator
  • Incorporates GenX Technology.
  • Latex Enhanced Immunoturbidometric Assay
  • 10 Minutes Fixed Time Reaction. (300 Sec + 300 Sec.).
  • Linearity: 10 mg/L
  • No prozone effect till the Cystatin reaches 60 mg/L
  • Excellent correlation to competitor methods – A correlation coefficient of r = 1.00 was obtained with
  • another commercially available methods
  • No interference from Bilirubin Conjugated: 50 mg/dL, Bilirubin Unconjugated: 20 mg/dL , Hemoglobin: 900 mg/dL, Triglyceride: 940 mg/dL, Rheumatoid Factor: 800 IU/mL
  • Un hemolyzed serum and Heparinized Plasma are the only specimens
  • Available as multipurpose reagents and dedicated system packs
Fructosamine
GenX – Fructosamine
  • Liquid Stable, Ready to use Two Reagents with Calibrator
  • Incorporates GenX Technology.
  • 10 Minutes Fixed Time Reaction. (300 Sec + 300 Sec.).
  • Linearity: 10 mMol/L
  • Measuring Wavelength 340 nm.
  • No interference from Bilirubin up to 20 mg/dL, Hemoglobin up to 200 mg/dL, Lipaemia up to 600 mg/dL, and Ascorbic acid up to 7 mg/dL.
  • Un hemolyzed serum is the only specimen
  • Available as multipurpose reagents and dedicated system packs
HDL Cholesterol Direct (5TH Gen / Detergent Selection / Immuno Inhibition)
GenX – HDL Cholesterol Direct (5TH Gen / Detergent Selection / Immuno Inhibition)
  • Liquid Stable, Ready to use Two Reagents
  • (3 Parts R1+ 1 Part R2)
  • Incorporates GenX Technology.
  • End Point and Fixed time procedures
  • 10 Minutes End Point Assay or 4 MinuteS Fixed Time Assay (60 Sec Delay+180 Sec Measuring)
  • Linearity 200 mg/dl
  • Results correlate with other reference methods.
  • Meets NCEP guidelines.
  • Works well with fasting & non fasting patient samples.
  • Precision with high triglyceride samples.
  • Measuring Wavelength 546 nm ( 540 – 630 nm)
  • Lyophilized Calibrator provided
  • Serum / Heparinized or EDTA Plasma as Specimens
  • Available as multipurpose reagents and dedicated system packs
Hemoglobin A1C
GenX – Hemoglobin A1C (Direct)
  • Liquid-stable, ready-to-use reagents
  • Particle Enhanced Immunoturbidimetric Test (PEIT)
  • Direct measurement of HbA1C, HB A1C Calibrator Provided
  • No need to measure Total hemoglobin.
  • Measuring range 15 – 150 mmol/mol (IFCC)/
  • Measuring range 3 – 16 % (DCCT/NGSP)
  • Wavelength 660 nmHbA1c liquid (two l)
  • Highly specific determination of HbA1c
  • No significant influence from a variety of hemoglobin variants and other interfering substances
  • Excellent precision
  • Standardized against IFCC, traceable to DCCT/NGSP
  • Results equivalent to HPLC method
Homocysteine
GenX – Homocysteine
  • Liquid Stable, Ready to use Two Reagents with Calibrator
  • Incorporates GenX Technology.
  • 10 Minutes Fixed time procedure (300 Sec Delay+300 Sec Measuring)
  • Linearity 46 µmol/L
  • Measuring Wavelength 340 nms
  • Serum / Heparinized or EDTA Plasma as Specimens
  • Standardized to NIST SRM 1955 (Homocysteine Standard Reference Material)
  • Measuring wavelength 340 nms
  • No interference from Bilirubin 20 mg/dL ,Haemoglobin 500 mg/dL, Red Blood Cell 0.4%,
  • Triglyceride (Intralipid solution) 500 mg/dL Glutathione 1000 µmol/L,Methionine 800 µmol/L,
  • Cysteine 200 µmol/L, Pyruvate 1250 µmol/L ? ±10
  • Available as multipurpose reagents and dedicated system packs
Alpha HBDH
GenX – Alpha Hydroxy Butyrate Dehydrogenase (HBDH) 5th Gen NADH Analogues
  • Liquid Stable, Ready to use Two Reagents
  • Incorporates GenX Technology
  • 5 Minutes decreasing kinetic assay (60 Sec Delay+ 240 Sec Measuring)
  • Results by kinetic factor
  • Linearity: 600 IU/L
  • Measuring Wavelength 340 nm.
  • No interference from Bilirubin up to 20 mg/dL, Hemoglobin up to 200 mg/dL, Triglycerides up to 1000
  • mg/dL,and Ascorbic acid up to 30 mg/dL.
  • Serum and Heparinized Plasma are the specimens
  • Available as multipurpose reagents and dedicated System Packs
D-3-Hydroxybutyrate
GenX – D-3-Hydroxybutyrate (Enzymatic/UV)
  • Liquid Stable, Ready to use Two Reagents
  • Incorporates GenX Technology
  • 5 Minutes decreasing Fixed Time assay (60 Sec Delay+ 240 Sec Measuring)
  • Aqueous Calibrator Provided.
  • Linearity: 3.5 mMol/L.
  • Measuring Wavelength 340 nm.
  • No interference from Bilirubin up to 25 mg/dL, Hemoglobin up to 300 mg/dL, Triglycerides up to 1000 mg/dl.
  • Serum and Heparinized/EDTA Plasma are the specimens
  • Available as multipurpose reagents and dedicated System Packs
Lactate (Colour)
GenX – Lactate (Colour)
  • Liquid Stable, Ready to use Two Reagents
  • Incorporates GenX Technology
  • 5 Minutes increasing Fixed Time assay (60 Sec Delay+ 240 Sec Measuring)
  • Aqueous Calibrator Provided.
  • Linearity: 15 mMol/L.
  • Measuring Wavelength 546 nm.
  • No interference from Bilirubin up to 20 mg/dL, Hemoglobin up to 500 mg/dL, Triglycerides up to 750 mg/dl.
  • Plasma collected in sodium fluoride/potassium oxalate is the recommended specimen
  • Available as multipurpose reagents and dedicated System Packs
LDL Cholesterol Direct (5TH Gen / Detergent Selection / Immuno Inhibition)
GenX – LDL Cholesterol Direct (5TH Gen / Detergent Selection / Immuno Inhibition)
  • Liquid Stable, Ready to use Two Reagents
  • (3 Parts R1+ 1 Part R2)
  • Incorporates GenX Technology.
  • End Point and Fixed time procedures
  • 10 Minutes End Point Assay or 4 Minutes Fixed Time Assay (60 Sec Delay+180 Sec Measuring)
  • Linearity 1200 mg/dl
  • Correlation with gold standard Beta quantification & Immuno separation.
  • Overcomes critical limitations of Friedewald formula.
  • Meets NCEP guidelines.
  • Works well with fasting & non fasting patient samples.
  • Precision with high triglyceride samples.
  • Measuring Wavelength 546 nm ( 540 – 630 nm)
  • Lyophilized Calibrator provided
  • Serum / Heparinized or EDTA Plasma as Specimens
  • Available as multipurpose reagents and dedicated system packs
Lipase (With Calibrator)
GenX – Lipase (Enzymatic/Colour)
  • Liquid ready to use two reagents (5 parts R1+ 1 part R2)
  • Uses Colorimetric Lipase Specific Substrate (1,2-O-dilauryl-rac-glycero-3-glutaric acid (6′-ethylresorufin)-ester)
  • Wide measuring range (Linearity): 2 – 250 IU/L
  • Measuring wavelength 578 nm.
  • Calibrator provided (Concentration batch specific)
  • Kinetic reaction time 3 minutes. (Semi Auto Analyzers)
  • Serum and Plasma are the specimens
  • Completely automated protocols – Available for a wide range of chemistry analyzers
  • Interference – The following interfering substances were not found to affect the assay:
  • Conjugated Bilirubin 40 mg/dl, Free Bilirubin 70 mg/dl, Haemoglobin 1000 mg/dl,
  • Conjugated Bilirubin 40 mg/dl, Free Bilirubin 70 mg/dl, Haemoglobin 1000 mg/dl,
Lipase (Without Calibrator/ Factor)
GenX – Lipase (Enzymatic/Colour)
  • Liquid ready to use two reagents (5 parts R1+ 1 part R2)
  • Uses Colorimetric Lipase Specific Substrate (1,2-O-dilauryl-rac-glycero-3-glutaric acid (6′-ethylresorufin)-ester)
  • Wide measuring range (Linearity): 2 – 250 IU/L
  • Measuring wavelength 578 nm.
  • Kinetic estimation with batch specific factor.
  • Kinetic reaction time 3 minutes. (Semi Auto Analyzers)
  • Serum and Plasma are the specimens
  • Completely automated protocols – Available for a wide range of chemistry analyzers
  • Interference – The following interfering substances were not found to affect the assay:
  • Conjugated Bilirubin 40 mg/dl, Free Bilirubin 70 mg/dl, Haemoglobin 1000 mg/dl,
  • Intralipid 800 mg/dl, Triglycerides 1000 mg/dl, Ascorbic Acid 40 mg/dl
NEFA (Non Esterified Fatty Acids)
GenX – NEFA (Non Esterified Fatty Acids)
  • Liquid Stable, Ready to use Two Reagents (With or without Calibrator)
  • 10 Minutes Kinetic/Fixed Time assay.
  • Linearity : 113 mg/dl or 4 mMol/L
  • Measuring Wavelength: 546 nm
  • Serum is the preferred specimen
Oxalate
GenX – Oxalate
  • Liquid Stable, Ready to use Two Reagents
  • 5 Minutes single step End Point /Fixed Time assay
  • Aqueous Oxalate Standard provided.
  • Linearity : 180 mg/24 Hours or 2 m Mol/24 Hours
  • Measuring Wavelength: 590 nm (570 – 630 nm)
  • 24 hour urine is the specimen.
Pyruvate
GenX – Pyruvate
  • Liquid Stable, Ready to use Three Reagents (R1+R2+ Deproteinization Reagent)
  • 5 Minutes Kinetic Decreasing Reaction (60 Sec Delay + 240 Sec Measuring)
  • Measuring Wavelength 340 nm.
  • Lineaty:10 mg/dl
  • Serum/ EDTA Plasma as specimens
Sodium (5 th Generation Dye Binding)
GenX Sodium (Na+) 5TH Gen (Dye Binding)
  • Liquid Stable, Ready to use Mono Reagent
  • Incorporates GenX Technology
  • 5 Minutes single step End Point reaction
  • Available as mono test packs
  • Interference from all the heavy metals is eliminated.
  • Potassium interference is eliminated
  • Results corelate with ISE, Direct/ Indirect Potentiometry & Flame Photometry.
  • Aqueous Sodium standard provided (Standard Conc: 100 mMol/L
  • Linearity : 200 mMol/L
  • Measuring Wavelength: 505 nm (490 – 550 nm)
  • Serum is the only specimen
  • Available as multipurpose reagents
Sodium & Potassium( 5 th Generation Dye Binding Na+ Colorimetric K+)
GenX SODIUM (Na+) POTASSIUM (K+) (COLORIMETRIC)
  • Liquid Stable, Ready to use Mono Reagent for Potassium
  • Liquid Stable, Ready to use Mono Reagent for Sodium
  • 5 Minutes single step End Point reaction (Potassium)
  • 5 Minutes single step End Point reaction (Sodium)
  • Results corelate with ISE, Direct/ Indirect Potentiometry & Flame Photometry.
  • Aqueous Sodium Potassium standard provided
  • (Standard Conc: Sodium 100 mMol/L,Potassium 5mMol/L
  • Linearity Sodium : 200 mMol/L, Potassium : 7 mMol/L
  • Measuring Wavelength for Sodium : 505 nm (490 – 550 nm)
  • Measuring Wavelength for Potassium : 578 nm (570 – 620 nm)
  • Serum is the only specimen
  • Available as multipurpose reagents
ZINC
GenX Zinc-ML (5-Brom-PAPS)
  • Liquid Stable, Ready to use Mono Reagent\
  • One step End Point assay.
  • Aqueous Zinc standard provided (Standard Conc: 200 µg/dl)
  • Linearity: 500 µg/dl)
  • Measuring Wavelength 546 nm (540 – 578 nm)
  • Serum/Plasma/Diluted Urine/Seminal Fluid are the specimens
  • Available as multipurpose reagents and dedicated system packs